ISSN 1662-4009 (online)

ey0019.8-1 | Mechanism of the year: neuropeptide substance P regulates aldosterone secretion | ESPEYB19

8.1. The developmental origin and the specification of the adrenal cortex in humans and cynomolgus monkeys

K Cheng , Y Seita , T Moriwaki , K Noshiro , Y Sakata , YS Hwang , T Torigoe , M Saitou , H Tsuchiya , C Iwatani , M Hosaka , T Ohkouchi , H Watari , T Umazume , K Sasaki

Sci Adv. 2022; 8(16): eabn8485. PMID: 35442744https://pubmed.ncbi.nlm.nih.gov/35442744/Brief Summary: This histologic and transcriptomic study of human and primate adrenal tissue samples provides a molecular framework to understand the fetal development of the adrenal gland.The adrenal cortex is the major source of steroid hormones that drive a plethora of critical ph...

ey0019.14-9 | Risk and Outcome | ESPEYB19

14.9. A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk

SA Williams , R Ostroff , MA Hinterberg , J Coresh , CM Ballantyne , K Matsushita , CE Mueller , J Walter , C Jonasson , RR Holman , SH Shah , N Sattar , R Taylor , ME Lean , S Kato , H Shimokawa , Y Sakata , K Nochioka , CR Parikh , SG Coca , T Omland , J Chadwick , D Astling , Y Hagar , N Kureshi , K Loupy , C Paterson , J Primus , M Simpson , NP Trujillo , P Ganz

Sci Transl Med. 2022 Apr 6;14(639):eabj9625; PMID 35385337 doi: 10.1126/scitranslmed.abj9625https://www.science.org/doi/10.1126/scitranslmed.abj9625Brief Summary: This international study, led by Dr. Stephens Williams from Boulder, Colorado, USA, developed a surrogate biomarker from 27 circulating proteins to predict ...